WO2001068814A3 - Multipotent cell and cardiomyocyte cell populations, and routes to and uses of same - Google Patents

Multipotent cell and cardiomyocyte cell populations, and routes to and uses of same Download PDF

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Publication number
WO2001068814A3
WO2001068814A3 PCT/US2001/007674 US0107674W WO0168814A3 WO 2001068814 A3 WO2001068814 A3 WO 2001068814A3 US 0107674 W US0107674 W US 0107674W WO 0168814 A3 WO0168814 A3 WO 0168814A3
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WO
WIPO (PCT)
Prior art keywords
same
populations
cellular
cardiomyocyte
cell
Prior art date
Application number
PCT/US2001/007674
Other languages
French (fr)
Other versions
WO2001068814A2 (en
Inventor
Loren J Field
Original Assignee
Advanced Res & Tech Inst
Loren J Field
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Res & Tech Inst, Loren J Field filed Critical Advanced Res & Tech Inst
Priority to CA002402245A priority Critical patent/CA2402245A1/en
Priority to JP2001567298A priority patent/JP2004504807A/en
Priority to AU2001243551A priority patent/AU2001243551A1/en
Priority to IL15160501A priority patent/IL151605A0/en
Priority to EP01916536A priority patent/EP1265987A2/en
Priority to US10/220,205 priority patent/US20030211088A1/en
Publication of WO2001068814A2 publication Critical patent/WO2001068814A2/en
Publication of WO2001068814A3 publication Critical patent/WO2001068814A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Abstract

Described are conduction cardiomyocyte-enriched cellular populations, and methods and materials for obtaining the same. The populations may be used to engraft mammalian myocardial tissue, for example to provide biological pacemakers. Also described are restorative cellular myocardial tissue, for example to provide biological pacemakers. Also described are restorative cellular myocardial grafts for improving the contractile function of injured segments of myocardium, and articles adapted for heart implantation (e.g. conductive pacemaker leads), which includes coatings of viable cardiomyocytes and optionally a carrier for the cardiomyocytes.
PCT/US2001/007674 2000-03-10 2001-03-12 Multipotent cell and cardiomyocyte cell populations, and routes to and uses of same WO2001068814A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002402245A CA2402245A1 (en) 2000-03-10 2001-03-12 Multipotent cell and cardiomyocyte cell populations, and routes to and uses of same
JP2001567298A JP2004504807A (en) 2000-03-10 2001-03-12 Multipotent cells and cardiomyocyte populations, and routes to the populations and uses thereof
AU2001243551A AU2001243551A1 (en) 2000-03-10 2001-03-12 Multipotent cell and cardiomyocyte cell populations, and routes to and uses of same
IL15160501A IL151605A0 (en) 2000-03-10 2001-03-12 Cardiomyocyte cell populations, methods for obtaining the same and devices utilizing the same
EP01916536A EP1265987A2 (en) 2000-03-10 2001-03-12 Multipotent cell and cardiomyocyte cell populations, and routes to and uses of same
US10/220,205 US20030211088A1 (en) 2001-03-12 2001-03-12 Multipotent cell and cardiomyocyte cell populations, and routes to and uses of same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18850700P 2000-03-10 2000-03-10
US60/188,507 2000-03-10

Publications (2)

Publication Number Publication Date
WO2001068814A2 WO2001068814A2 (en) 2001-09-20
WO2001068814A3 true WO2001068814A3 (en) 2002-05-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/007674 WO2001068814A2 (en) 2000-03-10 2001-03-12 Multipotent cell and cardiomyocyte cell populations, and routes to and uses of same

Country Status (6)

Country Link
EP (1) EP1265987A2 (en)
JP (1) JP2004504807A (en)
AU (1) AU2001243551A1 (en)
CA (1) CA2402245A1 (en)
IL (1) IL151605A0 (en)
WO (1) WO2001068814A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004535199A (en) 2001-07-12 2004-11-25 ジェロン コーポレイション Cardiomyocyte lineage cells produced from human pluripotent stem cells
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
AU2002359371A1 (en) 2001-11-08 2003-05-19 The Regents Of The University Of California Methods and compositions for correction of cardiac conduction disturbances
WO2004083375A2 (en) * 2003-03-21 2004-09-30 Gabriella Minchiotti Methods of promoting the differentiation of stem cells
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
JP4814875B2 (en) 2004-05-11 2011-11-16 アキシオジェネシス エージー Assay for drug discovery based on in vitro differentiated cells
WO2006021459A1 (en) * 2004-08-27 2006-03-02 Cell Center Cologne Gmbh Compositions and methods for modulating cell differentiation
US9062289B2 (en) 2005-06-22 2015-06-23 Asterias Biotherapeutics, Inc. Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells
CN100422739C (en) * 2006-04-13 2008-10-01 东南大学 Portable hypoxia operation box
US20110027234A1 (en) * 2007-04-11 2011-02-03 Technion Research & Development Foundation Ltd. Methods for identification and selection of human embryonic stem cell derived cells
JP2011510658A (en) 2008-01-30 2011-04-07 ジェロン・コーポレーション Synthetic surface for culturing stem cell-derived cardiomyocytes
WO2012098260A1 (en) 2011-01-21 2012-07-26 Axiogenesis Ag A non-viral system for the generation of induced pluripotent stem (ips) cells
US9592398B2 (en) 2011-05-12 2017-03-14 Medtronic, Inc. Leadless implantable medical device with osmotic pump
EP3452061B1 (en) 2016-05-02 2023-08-09 Emory University Uses of epithelial-to-mesenchymal inhibitors in generating pacemaker cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5103821A (en) * 1989-03-06 1992-04-14 Angeion Corporation Method of providing a biological pacemaker
WO1995014079A1 (en) * 1993-11-16 1995-05-26 Indiana University Foundation Myocardial grafts and cellular compositions useful for same
US6127176A (en) * 1998-06-10 2000-10-03 Cleveland Clinic Foundation Mutant cell lines unresponsive to interleukin 1

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5103821A (en) * 1989-03-06 1992-04-14 Angeion Corporation Method of providing a biological pacemaker
WO1995014079A1 (en) * 1993-11-16 1995-05-26 Indiana University Foundation Myocardial grafts and cellular compositions useful for same
US6127176A (en) * 1998-06-10 2000-10-03 Cleveland Clinic Foundation Mutant cell lines unresponsive to interleukin 1

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
GOURDIE R G ET AL: "THE SPATIAL DISTRIBUTION AND RELATIVE ABUNDANCE OF GAP-JUNCTIONAL CONNEXIN40 AND CONNEXIN43 CORRELATE TO FUNCTIONAL PROPERTIES OF COMPONENTS OF THE CARDIAC ATRIOVENTRICULAR CONDUCTION SYSTEM", JOURNAL OF CELL SCIENCE, ESSEX, GB, vol. 105, 1993, pages 985 - 991, XP000905088 *
GOURDIE ROBERT G ET AL: "Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 12, 9 June 1998 (1998-06-09), June 9, 1998, pages 6815 - 6818, XP002179468, ISSN: 0027-8424 *
KUPERSHMIDT SABINA ET AL: "Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system.", CIRCULATION RESEARCH, vol. 84, no. 2, 5 February 1999 (1999-02-05), pages 146 - 152, XP002179467, ISSN: 0009-7330 *
MALTSEV V A ET AL: "CARDIOMYOCYTES DIFFERENTIATED IN VITRO FROM EMBRYONIC STEM CELLS DEVELOPMENTALLY EXPRESS CARDIA-SPECIFIC GENES AND IONIC CURRENTS", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, vol. 75, no. 2, 1 August 1994 (1994-08-01), pages 233 - 244, XP000673463, ISSN: 0009-7330 *
MALTSEV VICTOR A ET AL: "Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinus nodal, atrial and ventricular cell types.", MECHANISMS OF DEVELOPMENT, vol. 44, no. 1, 1993, pages 41 - 50, XP000671041, ISSN: 0925-4773 *
OOSTHOEK PETRA W ET AL: "Immunohistochemical delineation of the conduction system: I. The sinoatrial node.", CIRCULATION RESEARCH, vol. 73, no. 3, 1993, pages 473 - 481, XP001028240, ISSN: 0009-7330 *
OOSTHOEK PETRA W ET AL: "Immunohistochemical delineation of the conduction system: II. The atrioventricular node and Purkinje fibers.", CIRCULATION RESEARCH, vol. 73, no. 3, 1993, pages 482 - 491, XP001028241, ISSN: 0009-7330 *
OYAMADA YUMIKO ET AL: "Differential regulation of gap junction protein (connexin) genes during cardiomyocytic differentiation of mouse embryonic stem cells in vitro.", EXPERIMENTAL CELL RESEARCH, vol. 229, no. 2, 1996, pages 318 - 326, XP002179469, ISSN: 0014-4827 *
WOBUS ANNA M ET AL: "Retinoic acid accelerates embryonic stem cell-derived cardiac differentiation and enhances development of ventricular cardiomyocytes.", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 29, no. 6, 1997, pages 1525 - 1539, XP002179466, ISSN: 0022-2828 *

Also Published As

Publication number Publication date
JP2004504807A (en) 2004-02-19
IL151605A0 (en) 2003-04-10
EP1265987A2 (en) 2002-12-18
AU2001243551A1 (en) 2001-09-24
CA2402245A1 (en) 2001-09-20
WO2001068814A2 (en) 2001-09-20

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