WO2008059521A3 - Novel process for the preparation of moxifloxacin hydrochloride and a novel polymorph of moxifloxacin - Google Patents

Novel process for the preparation of moxifloxacin hydrochloride and a novel polymorph of moxifloxacin Download PDF

Info

Publication number
WO2008059521A3
WO2008059521A3 PCT/IN2007/000448 IN2007000448W WO2008059521A3 WO 2008059521 A3 WO2008059521 A3 WO 2008059521A3 IN 2007000448 W IN2007000448 W IN 2007000448W WO 2008059521 A3 WO2008059521 A3 WO 2008059521A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel
moxifloxacin
preparation
polymorph
hydrochloride
Prior art date
Application number
PCT/IN2007/000448
Other languages
French (fr)
Other versions
WO2008059521A2 (en
Inventor
Reddy Manne Satyanarayana
Chakilam Nagaraju
Rajan Srinivasan Thirumalai
Ramprasad Achampeta Kodanda
Revu Satyanarayana
Original Assignee
Msn Lab Ltd
Reddy Manne Satyanarayana
Chakilam Nagaraju
Rajan Srinivasan Thirumalai
Ramprasad Achampeta Kodanda
Revu Satyanarayana
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Lab Ltd, Reddy Manne Satyanarayana, Chakilam Nagaraju, Rajan Srinivasan Thirumalai, Ramprasad Achampeta Kodanda, Revu Satyanarayana filed Critical Msn Lab Ltd
Priority claimed from IN1345CH2007 external-priority patent/IN2007CH01345A/en
Publication of WO2008059521A2 publication Critical patent/WO2008059521A2/en
Publication of WO2008059521A3 publication Critical patent/WO2008059521A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

The present invention relates to a novel process for the preparation of moxifloxacin hydrochloride compound of formula-1 through novel quinoline carboxamide intermediate compounds of general formula-2. The present invention provides the process for the preparation of novel quinoline carboxamide intermediate compounds of general formula-2. The present invention also relates to a novel process for the preparation of anhydrous form of moxifloxacin hydrochloride and a novel crystalline form of moxifloxacin.
PCT/IN2007/000448 2006-11-14 2007-09-27 Novel process for the preparation of moxifloxacin hydrochloride and a novel polymorph of moxifloxacin WO2008059521A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2111CH2006 2006-11-14
IN2111/CHE/2006 2006-11-14
IN1345/CHE/2007 2007-06-25
IN1345CH2007 IN2007CH01345A (en) 2004-10-01 2007-09-27

Publications (2)

Publication Number Publication Date
WO2008059521A2 WO2008059521A2 (en) 2008-05-22
WO2008059521A3 true WO2008059521A3 (en) 2008-08-28

Family

ID=39402100

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000448 WO2008059521A2 (en) 2006-11-14 2007-09-27 Novel process for the preparation of moxifloxacin hydrochloride and a novel polymorph of moxifloxacin

Country Status (1)

Country Link
WO (1) WO2008059521A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2154137A1 (en) 2008-08-04 2010-02-17 Chemo Ibérica, S.A. Crystalline form of moxifloxacin base
US20110212990A1 (en) * 2008-11-06 2011-09-01 Hetero Research Foundation Novel polymorph of moxifloxacin hydrochloride
CN102030751B (en) * 2010-12-01 2012-11-21 上虞京新药业有限公司 Process for crystallizing moxifloxacin hydrochloride
KR101435244B1 (en) * 2011-04-12 2014-08-29 씨제이헬스케어 주식회사 Moxifloxacin formulation and method of preparing the same
UA106556C2 (en) * 2013-05-13 2014-09-10 Наталья Николаевна Деркач Method of obtaining (1-cyclopropyl -6- fluoro-1,4-dihydro methoxy -8 -7 - [(4as, 7as) - oktahydro -6n- pyrrolo [3,4-pyridine bsch - 6- yl] -4-oxo-3-hinolinkarbonovoyi acid
WO2015093669A1 (en) * 2013-12-20 2015-06-25 씨제이헬스케어 주식회사 Aqueous formulation of moxifloxacin and preparation method therefor
US20220323448A1 (en) * 2017-05-04 2022-10-13 Ocular Science, Inc. Compositions and methods for treating eyes and methods of preparation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0443498A1 (en) * 1990-02-19 1991-08-28 Kyorin Pharmaceutical Co., Ltd. Isoindoline derivatives
EP0550903A1 (en) * 1992-01-10 1993-07-14 Bayer Ag Quinolone- and naphthyridone carboxylic acid derivatives as antibacterial agents
US6323213B1 (en) * 1996-02-23 2001-11-27 Bayer Aktiengesellschaft Possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives
WO2005012285A1 (en) * 2003-08-05 2005-02-10 Matrix Laboratories Ltd An improved process for the preparation of moxifloxacin hydrochloride

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0443498A1 (en) * 1990-02-19 1991-08-28 Kyorin Pharmaceutical Co., Ltd. Isoindoline derivatives
EP0550903A1 (en) * 1992-01-10 1993-07-14 Bayer Ag Quinolone- and naphthyridone carboxylic acid derivatives as antibacterial agents
US6323213B1 (en) * 1996-02-23 2001-11-27 Bayer Aktiengesellschaft Possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives
WO2005012285A1 (en) * 2003-08-05 2005-02-10 Matrix Laboratories Ltd An improved process for the preparation of moxifloxacin hydrochloride

Also Published As

Publication number Publication date
WO2008059521A2 (en) 2008-05-22

Similar Documents

Publication Publication Date Title
WO2008059521A3 (en) Novel process for the preparation of moxifloxacin hydrochloride and a novel polymorph of moxifloxacin
WO2009066326A3 (en) Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts
WO2008059223A3 (en) Process for the synthesis of moxifloxacin hydrochloride
WO2010105179A3 (en) Inhibitors of beta-secretase
TWI370121B (en) Process for the preparation of a 2-pyridylethylcarboxamide derivative
WO2007010555A3 (en) Novel crystalline forms of moxifloxacin hydrochloride and process for preparation thereof
WO2011141933A3 (en) Process for preparation of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid and its pharmaceutically acceptable salts
WO2008155615A3 (en) An improved process for the preparation of cephalosporin antibiotic
WO2010027236A3 (en) Fused heterocyclic compound
WO2010036329A3 (en) Process for making quinolone compounds
WO2007057225A3 (en) Process for making montelukast and intermediates therefor
WO2010001257A3 (en) Novel solid state forms of laquinimod and its sodium salt
WO2008049645A3 (en) Hydrates of erlotinib hydrochloride
WO2006066044A3 (en) Processes for producing 4-aminoquinazolines
WO2006023659A3 (en) Novel polymorphs of azabicyclohexane
EP2039691A4 (en) Process for production of a polymorph of 2-(3-cyano-4- isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid
WO2007096875A3 (en) Novel polymorphs of montelukast ammonium salts and processes for preparation therefor
WO2007099552A3 (en) Novel crystalline form of atovastatin hemi-magnesium
WO2008034912A3 (en) Process for the synthesis of clopidogrel and new forms of pharmaceutically acceptable salts thereof
WO2011135586A3 (en) Process for the preparation of chiral beta amino carboxamide derivatives
WO2008008327A3 (en) Xinafoate salt of a substituted 5-oxazol-2-yl-quinoline compound
WO2009060297A3 (en) An improved process for the preparation of paliperidone and its intermediates
EA200900926A1 (en) METHOD FOR PRODUCING MONOHYDROCHLORIDE 8-HYDROXY-5 - [(1R) -1-HYDROXY-2 [[(1R) -2- (4-METHOXYPHENYL) -1-METHYLETHYL] AMINO] ETHYL] -2 (1H) -CHINOLINONE
WO2008007391A3 (en) An improved process for the preparation of valsartan
HK1117141A1 (en) Process for the preparation of a new crystalline atorvastatin hemicalcium salt polymorph form

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07827588

Country of ref document: EP

Kind code of ref document: A2

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07827588

Country of ref document: EP

Kind code of ref document: A2

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)